| Autor: |
Jerry R. McGhee, Hiroshi Kiyono, T. Kurita, M. L. McGHEE |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Recent Advances in Mucosal Immunology ISBN: 9781468453461 |
| DOI: |
10.1007/978-1-4684-5344-7_11 |
| Popis: |
T cell subsets which express Fc receptors for immunoglobulin (FcR) are important in isotype-specific regulation of B cell responses (1). These FcR+ T cells secrete isotype-specific immunoglobulin binding factors (IBF) which recognize specific Fc regions of immunoglobulin (Ig) and IBF can up or down regulate B cell antibody synthesis in these Ig classes. In this regard, allo-activated T cells which bear Fc receptors for IgG (FcγR) and the T2D4 T cell line (FcγR+ and FcαR+) release IgG binding factor (IBFγ) and suppress this isotype for in vitro responses (2). In the IgE system, Fc receptors for IgE (FceR) occur on T cells which regulate this isotype response via production of either enhancing or suppressive IgE binding factors (IBFe) (3). Both potentiating and suppressive IBFe are similar in size (Mr ~15,000). They contain a common protein core, and the degree of glycosylation determines whether IBFe enhances or suppresses the IgE responses. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
