Anti-human immunodeficiency and anti-hepatitis B virus activities of β-l-2′,3′-dideoxy purine nucleosides
| Autor: | Peiyuan Wang, V. Boudou, Abdesselem Faraj, Abdelaziz el Alaoui, Chung K. Chu, Jean-Louis Imbach, Claire Pierra, Yong-Lian Zhu, Ju-Sheng Lin, Raymond F. Schinazi, Jean-Pierre Sommadossi, Christophe Mathé, Gilles Gosselin, P. J. Bolon, S. Balakrishna Pai, Yung-Chi Cheng |
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| Rok vydání: | 1996 |
| Předmět: |
Hepatitis B virus
Purine Chemistry Organic Chemistry Clinical Biochemistry Human immunodeficiency virus (HIV) Pharmaceutical Science medicine.disease_cause Biochemistry Molecular biology In vitro chemistry.chemical_compound Cell culture Drug Discovery medicine Molecular Medicine Stereoselectivity Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:1657-1662 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/0960-894x(96)00293-4 |
| Popis: | β- l -2′,3′-Dideoxyadenosine, β- l -2′,3′-didehydro-2′,3′-dideoxyadenosine and related compounds were synthesized in a stereoselective manner. These compounds were tested in vitro against HBV in 2.2.15 cell line and against HIV-1 in PBM and CEM cells. It was found that β- l -2′,3′-dideohydro-2′,3′-dideoxyadenosine ( 7 ) exhibited significant anti-HIV (EC 50 0.38 μM in PBM cells) and anti-HBV activity (EC 50 1.2 μM). |
| Databáze: | OpenAIRE |
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