Immunohistochemical localization of angiotensin AT 1 receptors in the rat carotid body
| Autor: | Angel D. Dandov, Nikolai Lazarov, Dimitrinka Atanasova, Nikolay Dimitrov |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Superior cervical ganglion
medicine.medical_specialty Histology Angiotensin II receptor type 1 Chemistry Cell Biology General Medicine 030204 cardiovascular system & hematology Angiotensin II 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Glomus cell Endocrinology Losartan Internal medicine cardiovascular system medicine Carotid body Receptor hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Immunostaining circulatory and respiratory physiology medicine.drug |
| Zdroj: | Acta Histochemica. 120:154-158 |
| ISSN: | 0065-1281 |
| DOI: | 10.1016/j.acthis.2018.01.005 |
| Popis: | The carotid body (CB) is a major peripheral arterial chemoreceptor that initiates respiratory and cardiovascular adjustments to maintain homeostasis. Recent evidence suggests that circulating or locally produced hormones like angiotensin II acting via AT1 receptors modulate its activity in a paracrine-autocrine manner. The aim of this study was to examine the immunohistochemical localization of AT1 receptor in the CB of adult rats and to compare its expression in vehicle-treated animals, and after the long-term application of its selective blocker losartan. Immunohistochemistry revealed that a subset of CB glomeruli and the vast majority of neurons in the adjacent superior cervical ganglion (SCG) were strongly AT1 receptor-immunoreactive. In the CB immunostaining was observed in the chemosensory glomus cells typically aggregated in cell clusters while the nerve fibers in-between and large capillaries around them were immunonegative. Exogenous administration of losartan for a prolonged time significantly reduces the intensity of AT1 receptor immunostaining in the CB glomus cells and SCG neurons. Our results show that AT1 receptors are largely expressed in the rat CB under physiological conditions, and their expression is down-regulated by losartan treatment. |
| Databáze: | OpenAIRE |
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