PARK11 and Gut-microbiota in Parkinson’s disease----- Is there a link?
| Autor: | Eva Ramos-Llica, Monica Guadalupe Retuerto Figueroa, Arilmi Gorriti Gutierrez, Celia Vargas de la Cruz, Shariful Islam, Sixto Gonzalez Elera, César Fuertes Ruitón, Teresa Gallardo Jugo |
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| Rok vydání: | 2020 |
| Předmět: |
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Parkinson's disease biology business.industry Central nervous system Substantia nigra Disease Gut flora medicine.disease biology.organism_classification LRRK2 General Biochemistry Genetics and Molecular Biology nervous system diseases medicine.anatomical_structure Immunology medicine Synuclein General Pharmacology Toxicology and Pharmaceutics medicine.symptom business |
| Zdroj: | Journal of critical reviews. 7 |
| ISSN: | 2394-5125 |
| DOI: | 10.31838/jcr.07.01.89 |
| Popis: | Parkinsons disease is a genetically heterogeneous, idiopathic and metacentric neurodegenerative disease of the nervous system characterized by progressive generalized slowing movements like bradykinesia, weakness, tremor, and rigidity, and postural instability in along with Parkinsons disease has been pondered to be a non-genetic distemper. A different way, features are associated such as sleep dysfunction, loss of smell, mood disorder, constipation, excessive salivation, and excessive periodic limb movements in sleep. Feudatory factors encompass head injury, pesticide exposure, and agriculture background. Results with development and assembling of α- synuclein in the central nervous system in the substantia nigra. A little while back, in North American, Parkinsons disease is a significant relationship indicated to 39.5cM of chromosome 2 (2q36-37; PARK11) portion on the deep arm. Immune-related disorder, notably Crohns and leprosy diseases are also associated with Parkinsons disease, however around 15% persona with Parkinsons disease have primary level correlative who has the distemper in the genes including LRRK2, SNCA, last one GBA found as a keek part for sporadic Parkinsons disease. |
| Databáze: | OpenAIRE |
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