Diagnostic and prognostic role of markers of inflammation and vascular endothelial growth factor in infectious endocarditis

Autor:	A. P. Roitman, N. A. Semenenko, T. A. Fedorova, Serafima Ya. Tazina, M. K. Rybakova, V. I. Burtsev
Rok vydání:	2017
Předmět:	Vascular endothelial growth factor chemistry.chemical_compound Pathology medicine.medical_specialty chemistry business.industry Medicine Endocarditis Inflammation General Medicine medicine.symptom business medicine.disease
Zdroj:	Clinical Medicine (Russian Journal). 95:618-622
ISSN:	2412-1339 0023-2149
DOI:	10.18821/0023-2149-2017-95-7-618-622
Popis:	The peculiarities of primary and secondary infective endocarditis (IE) were studied in 62 patients with primary and secondary IE, uncomplicated and complicated disease treated in S. P. Botkin city clinical hospital including analysis of dynamics of tumor necrosis factor α (TNF α), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) within 3 weeks after the onset of antibiotic therapy. A rise in TNF α and IL-6 levels was shown to correlate with the severity of the disease and the development of infectious-toxic syndrome. Most patients had an increased level of VEGF, a mediator involved in the regulation of inflammation. It was shown that combination of high TNF-α and IL-6 levels with the initially low or gradually increasing VEGF levelsuggests the unfavourable prognosis characteristic of the most heavily diseased anddeceased patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::866476ea89dd591aeb75f780021772a7 https://doi.org/10.18821/0023-2149-2017-95-7-618-622 Zobrazit plný text záznamu