Charantoside L, A New Cucurbitane-Type Glycoside from Momordica charantia L. with α-Glucosidase Inhibitory Activities
| Autor: | Duong Thi Hai Yen, Pham Hai Yen, Nguyen Quang Hop, Nguyen Anh Hung, Ha Thi Thu Tran, Bui Huu Tai, Nguyen Xuan Nhiem, Phan Van Kiem |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Natural Product Communications. 17:1934578X2110689 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x211068924 |
| Popis: | A new cucurbitane-type glycoside (1) and two known compounds (2-3) were isolated from the ethanol extract of the fruits of Momordica charantia L. Their chemical structures were determined as (19 S,23 E)-5 β,19-epoxy-19-methoxycucurbita-6,23-diene-3 β,25-diol 3 -O-β-D-allopyranoside (1), goyaglycoside d (2), and (19 S,23 E)-5 β,19-epoxy-19-methoxycucurbita-6,23-diene-3 β,25-diol (3) on the basis of the extensive spectroscopic methods, including 1D, 2D NMR, HRESIMS, and in comparison with the reported data. Compounds 1 to 3 were evaluated for α-glucosidase inhibitory effects. Compounds 1 and 2 showed anti α-glucosidase activity with IC50 values of 134.12 ± 11.20 and 163.17 ± 13.71 µM, respectively, compared with the positive control, acarbose, IC50 160.99 ± 14.30 μM. Compounds 2 and 3 were first isolated from plant M. charantia growing in Vietnam. |
| Databáze: | OpenAIRE |
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