Anti-Allergy Properties of PRD-92 Ea in Guinea Pig and Rat

Autor:	J. Morley, J.L. Beets, H.M. Meade
Rok vydání:	1980
Předmět:	business.industry Immunology Antagonist Bradykinin Vascular permeability General Medicine Extravasation Guinea pig chemistry.chemical_compound chemistry In vivo Immunology and Allergy Medicine business Histamine 5-HT receptor
Zdroj:	International Archives of Allergy and Immunology. 61:449-456
ISSN:	1423-0097 1018-2438
Popis:	The effects of PRD-92 Ea were examined on the increased plasma protein extravasation in the skin of guinea pig and rat elicited by specific antigens and spasmogenic mediators. PRD-92 Ea was found to be a potent inhibitor of rat PCA reactions when administered intradermally, intravenously or orally. This compound did not antagonize the local inflammatory responses of histamine, bradykinin or 5HT. This implies that in vivo PRD-92 Ea acts predominantly as an anti-allergy agent rather than a spasmogen antagonist. At high concentrations PRD-92 Ea directly increased vascular permeability when injected intradermally (> 250 μg/site) or administered by aerosol into the lung (> 10%). The importance of investigating such direct irritant actions of similar new drugs is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::865dc71b2aae404103c5b8bfe2b34c07 https://doi.org/10.1159/000232473 Zobrazit plný text záznamu