Optimization of metabolic criteria in the prognostic assessment of patients with lymphoma. A multicenter study
| Autor: | P. Bassa Massanas, M. del Puig Cózar-Santiago, J.R. García-Garzón, M. Soler-Peter, R. Sanchez-Jurado, M. Sánchez-Delgado, M. Moragas-Freixa, J. Ferrer-Rebolleda, J.E. Aguilar-Barrios, R. Sanz-Llorens |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
business.industry General Engineering Follicular lymphoma medicine.disease Gastroenterology 030218 nuclear medicine & medical imaging Lymphoma 03 medical and health sciences 0302 clinical medicine Multicenter study 030220 oncology & carcinogenesis Internal medicine Statistical significance medicine General Earth and Planetary Sciences Hodgkin lymphoma Statistical analysis In patient Nuclear medicine business Diffuse large B-cell lymphoma General Environmental Science |
| Zdroj: | Revista Española de Medicina Nuclear e Imagen Molecular (English Edition). 36:304-311 |
| ISSN: | 2253-8089 |
| DOI: | 10.1016/j.remnie.2017.06.006 |
| Popis: | Objective To compare sensitivity (Se), specificity (Sp) and predictive value of Deauville score (DS) vs ΔSUVmax in iPET and ePET, in patients with diffuse large B cell lymphoma (DLBCL), Hodgkin lymphoma (HL), and follicular lymphoma (FL). Method Retrospective longitudinal multicentre study including 138 patients (46 DLBCL, 46 HL, 46 FL), on whom three 18F-FDG PET/CT were performed: baseline (bPET), mid-treatment or interim (iPET), and end-treatment (ePET). Visual (DS) and semi-quantitative (ΔSUVmax) parameters were determined for iPET and ePET. Predictive value was determined in relation to disease-free interval (DFI). Results Statistical analysis. iPET for DLBCL, HL, and FL: (1) Se of DS: 76.92%; 83.33%; 61.53%; Sp: 78.78%; 85%; 81.81%; (2) Se of ΔSUVmax: 53.84%; 83.33%; 61.53%; Sp: 87.87%; 87.50%; 78.78%. ePET for DLBCL, HL and FL: (1) Se of D: 61.53%; 83.33%; 69.23%; Sp: 90.90%; 85%; 87.87%; (2) Se of ΔSUVmax: 69.23%; 83.33%; 69.23%; Sp: 90.90%; 87.50%; 84.84%. Predictive assessment. iPET study: (1) in DLBCL, DS resulted in 10.3% recurrence of negative iPET, and 17.1% in ΔSUVmax at DFI; (2) in HL, both parameters showed a 2.8% recurrence of negative iPET; (3) in FL, DS resulted in 15.6% recurrence of negative iPET, and 16.1% in ΔSUVmax 16.1%, with no statistical significance. ePET study: (1) in DLBCL, DS resulted in 14.3% recurrence of negative ePET, and 11.8% in ΔSUVmax at DFI; (2) in HL and FL, both methods showed 2.8% and 12.5% recurrence in negative ePET. Conclusions DS and ΔSUVmax did not show significant differences between DLBCL, HL and FL. Furthermore, their predictive values did not show significant differences between HL and FL. In DLBCL, DS was higher in iPET, and ΔSUVmax in ePET. |
| Databáze: | OpenAIRE |
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