Polymorphism of genes of the antioxidant system in the development of predispositions to lung cancer

Autor:	Yu. E. Kulemin, Elena N. Voronina, Olga A. Soboleva, Varvara I. Minina, Anastasia V. Ryzhkova, Ruslan A. Titov
Rok vydání:	2017
Předmět:	0301 basic medicine Genetics chemistry.chemical_classification GPX1 Locus (genetics) Biology medicine.disease Human genetics 03 medical and health sciences GSTP1 030104 developmental biology Enzyme chemistry medicine Allele Lung cancer Gene
Zdroj:	Russian Journal of Genetics. 53:903-909
ISSN:	1608-3369 1022-7954
DOI:	10.1134/s1022795417080117
Popis:	We analyzed the polymorphic loci in the genes of the antioxidant system enzymes, such as GSTP1 (313A>G and 341C>T), MnSOD (47С>Т), GPx1 (599C>T), and CAT (–262C>>T), among 497 residents of Kemerovo oblast (Western Siberia, Russia). The analysis of the single-locus effects demonstrated a significant protective effect of the major C allele in the GPx1 (599C>T) locus. The MDR analysis of the gene-gene interactions showed that the GPx1 and the CAT genes work in close cooperation and mutually reinforce the risk of development of squamous cell lung cancer among the inhabitants of the industrial region.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8657d28c101ca400b6f01f83dda9e5d8 https://doi.org/10.1134/s1022795417080117 Zobrazit plný text záznamu Full text from SpringerLink