Antimicrobial potential of alkalophilic micromycetes Emericellopsis alkalina
| Autor: | V. S. Sadykova, M. L. Georgieva, Ya. A. Andreev, Anna A. Baranova, E. N. Bilanenko, E. A. Rogozhin |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification biology Edman degradation 010405 organic chemistry medicine.drug_class Aspergillus niger Antimicrobial peptides Antibiotics Peptide biology.organism_classification Antimicrobial 01 natural sciences Applied Microbiology and Biotechnology Biochemistry 0104 chemical sciences Microbiology 03 medical and health sciences 030104 developmental biology Emericellopsis alkalina chemistry Pathogenic yeast medicine |
| Zdroj: | Applied Biochemistry and Microbiology. 53:703-710 |
| ISSN: | 1608-3024 0003-6838 |
| DOI: | 10.1134/s0003683817060035 |
| Popis: | The ability of alkalophilic micromycetes of the Emericellopsis alkalinа to produce antimicrobial peptides has been studied. Evaluation of the spectrum and the yield of antibiotic compounds has allowed us to choose a promising producer of peptide antimycotics, Emericellopsis аlkalinа А118. The producer exhibits antifungal activity against conditionally pathogenic yeast and mold fungi, i.e., Candida аlbicans, Aspergillus niger, and A. fumigatus. The group of homologous active compounds isolated by the set of identified structural features (molecular weight, the ratio of the absorption at certain wavelengths, and the absence of initiation of Edman sequencing) may be attributed to peptaibols, which are a group of nonribosomal membrane-active antimicrobial peptides with a specificity of action primarily against fungi-micromycetes. |
| Databáze: | OpenAIRE |
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