| Autor: |
J.P. Vestey, J.P. Maingay, W. A. Neill, M. Norval, S. E. M. Howie |
| Rok vydání: |
2015 |
| Předmět: |
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| Popis: |
Nine patients with eczema herpeticum (EH) and 2 with atopic eczema and recurrent cold sores were investigated for cell-mediated immunity (CMI) and antibodies (Ab) to herpes simplex virus (HSV). All patients had Ab to HSV and a high lymphoproliferation response to concanavalin A and all but 3 showed lymphoproliferation to HSV antigens. These 3 patients had very severe EH and absent CMI to HSV for many months after clinical recovery despite normal Ab and concanavalin A responses. In 2 of them, depletion of CD8+ T cells by panning restored the lymphoproliferative response to HSV. Thus their absent CMI may be due to suppressor cell function rather than lack of responsive cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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