Radical cyclization of 1,6-dienes with azobis(alkylcarbonitriles) on water under additive-free conditions

Autor:	Zhiyong Guo, Fu-Hua Qin, Qianjun Shao, Wen-Ting Wei, Yi Liu, Xun-Jie Huang, Dapeng Wu, Qiang Li, Ya-Nan Meng
Rok vydání:	2020
Předmět:	Reaction conditions Solvent Tandem Chemistry Environmental Chemistry Organic chemistry Regioselectivity Pollution Radical cyclization
Zdroj:	Green Chemistry. 22:4593-4596
ISSN:	1463-9270 1463-9262
DOI:	10.1039/d0gc00140f
Popis:	Without using any additives, a practical and eco-friendly methodology has been realized for the tandem double cyclization of 1,6-dienes with easily accessible azobis(alkylcarbonitriles) on water. This chemistry has mild reaction conditions, employing water as the sole solvent, with high regioselectivity and ease of scale-up. Moreover, this is the first example of 1,n-diene cyclization using azobis(alkylcarbonitriles) as a two-carbon unit for the construction of polycyclic skeletons.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::864a74e7c79f14ed633d60830b54bb29 https://doi.org/10.1039/d0gc00140f Zobrazit plný text záznamu