Solving puzzles of aging: From disposable soma to signal-transduction pathways

Autor:	M. V. Blagosklonny
Rok vydání:	2010
Předmět:	Genetic Processes medicine.anatomical_structure Life span Chemistry Calorie restriction medicine Cellular senescence Soma General Chemistry Signal transduction Neuroscience
Zdroj:	Russian Journal of General Chemistry. 80:1407-1414
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363210070364
Popis:	Aging is believed to be caused by accumulation of unrepaired damage. The repair is believed to be limited by energetic resources. A testable prediction is: the less resources (calorie restriction), the shorter lifespan. In contrast, calorie restriction extends life span. To explain the conflicting result, paradoxical “allocation of resources” was proposed, thus creating the “odd science of aging.” However, evidence emerges that aging is not driven by damage but instead is driven by nutrient-activated signaling pathways such as TOR (target of rapamycin). This immediately explains how calorie restriction extends life span and solves all “odd” puzzles of aging. Here I suggest that aging is neither random damage nor a program but instead is a quasiprogram (a harmful continuation of valuable developmental programs). It is a genetic process that can be slowed down pharmacologically. And several drugs that directly or indirectly inhibit TOR are available for clinical use.
Databáze:	OpenAIRE
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