Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine scaffolds
| Autor: | Ahmed El-Mekabaty, Başak Doğru Mert, Khaled M. Elattar, Mohamed Monier |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Pyrimidine 010405 organic chemistry General Chemical Engineering General Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences Combinatorial chemistry 0104 chemical sciences Coordination complex chemistry.chemical_compound chemistry Nucleophile Amide Reactivity (chemistry) |
| Zdroj: | RSC Advances. 10:15461-15492 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/d0ra00411a |
| Popis: | Heterocycles incorporating a pyrimidopyrimidine scaffold have aroused great interest from researchers in the field of medical chemistry because of their privileged biological activities; they are used as anti-bacterial, antiviral, anti-tumor, anti-allergic, antihypertensive, anticancer, and hepatoprotective agents. Therefore, the present study aims to investigate the chemistry of heterocycles incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine skeletons and their biological characteristics. The main sections discuss (1) the synthetic routes to obtain substituted pyrimidopyrimidines, pyrimido[1,6-a]pyrimidin-diones, pyrimidoquinazolines, tricyclic, tetracyclic, and binary systems; (2) the reactivity of the substituents attached to the pyrimidopyrimidine skeleton, including thione and amide groups, nucleophilic substitutions, condensations, ring transformations, and coordination chemistry; (3) compounds of this class of heterocycles containing a significant characteristic scaffold and possessing a wide range of biological characteristics. |
| Databáze: | OpenAIRE |
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