Cytomegalovirus infection associated with clonal proliferation of T-cell large granular lymphocytes

Autor:	Kit-Fai Wong, Sze-Fai Yip, G.T.C. Lau, C.C So, Y.M. Yeung
Rok vydání:	2003
Předmět:	Cancer Research Lymphocytosis T cell CD3 T-cell receptor Congenital cytomegalovirus infection chemical and pharmacologic phenomena Gene rearrangement Biology medicine.disease Leukemia medicine.anatomical_structure Immunology Genetics medicine biology.protein medicine.symptom Molecular Biology CD8
Zdroj:	Cancer Genetics and Cytogenetics. 142:77-79
ISSN:	0165-4608
DOI:	10.1016/s0165-4608(02)00739-2
Popis:	Clonal proliferation of T-cell large granular lymphocytes (LGL) is an indolent disorder characterized by splenomegaly, lymphocytosis and frequent manifestations of immune disturbances. The LGL are CD3 + CD4 − CD8 + CD56 − . The clonality of the tumor cell population is often only demonstrable by T-cell receptor ( TCR ) gene rearrangement study because chromosomal abnormality is distinctly rare. We describe a case of T-cell LGL leukemia that presented initially as cytomegalovirus infection. The leukemic LGL are shown to be clonal by both TCR gene rearrangement and chromosomal studies. They persist after subsidence of the cytomegalovirus infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::862b44af48131d36ed705483d451618e https://doi.org/10.1016/s0165-4608(02)00739-2 Zobrazit plný text záznamu Full Text from ScienceDirect