Copper-Mediated Synthesis of Aryldifluoromethylphosphonates: A Sandmeyer Approach

Autor:	Xavier Pannecoucke, Olivier R. Martin, Alexandre Bayle, Cyril Nicolas, Chloé Cocaud, Thomas Poisson
Rok vydání:	2015
Předmět:	chemistry.chemical_compound General method Chemistry Aryl Organic Chemistry Copper mediated Sandmeyer reaction Fluorine Moiety Organic chemistry chemistry.chemical_element Physical and Theoretical Chemistry Copper
Zdroj:	European Journal of Organic Chemistry. 2015:3787-3792
ISSN:	1434-193X
Popis:	Difluoromethylated arenes are scaffolds of great interest. We report herein a mild and general method for the introduction of the CF2PO(OEt)2 moiety into arenes. The CuCF2PO(OEt)2 species, which is generated in situ from the corresponding silylated derivatives, in combination with aryl diazonium salts furnished the highly valuable aryl difluoromethylphosphonates in moderate to good yields. This represents the first general method to introduce difluoromethylphosphonates under mild conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::86294eeb21aef94cbefb463a72dbdaab https://doi.org/10.1002/ejoc.201500373 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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