ChemInform Abstract: KAT(ching) Metabolism by the Tail: Insight into the Links Between Lysine Acetyltransferases and Metabolism

Autor:	Kevin M. Arnold, Brittany N. Albaugh, John M. Denu
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Lysine Acetyltransferases biology Metabolite General Medicine Metabolism Chromatin chemistry.chemical_compound Histone Enzyme Biochemistry chemistry Acetylation biology.protein Epigenetics
Zdroj:	ChemInform. 42
ISSN:	0931-7597
DOI:	10.1002/chin.201119267
Popis:	Post-translational modifications of histones elicit structural and functional changes within chromatin that regulate various epigenetic processes. Epigenetic mechanisms rely on enzymes whose activities are driven by coenzymes and metabolites from intermediary metabolism. Lysine acetyltransferases (KATs) catalyze the transfer of acetyl groups from acetyl-CoA to epsilon amino groups. Utilization of this critical metabolite suggests these enzymes are modulated by the metabolic status of the cell. This review highlights studies linking KATs to metabolism. We cover newly identified acyl modifications (propionylation and butyrylation), discuss the control of KAT activity by cellular acetyl-CoA levels, and provide insights into how acetylation regulates metabolic proteins. We conclude with a discussion of the current approaches to identifying novel KATs and their metabolic substrates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8626f0a5bf634c38e3cff351c5f84367 https://doi.org/10.1002/chin.201119267 Zobrazit plný text záznamu Plný text