Perspectives on the in vitro evaluation of anti-anaphylactic agents

Autor:	Stephen M. Coutts, Ira Weinryb, Atul Khandwala
Rok vydání:	1983
Předmět:	biology business.industry Basophil Granulocyte Tachyphylaxis Immunoglobulin E medicine.disease Mast cell In vitro medicine.anatomical_structure Drug Discovery Disodium cromoglycate Immunology medicine biology.protein business Anaphylaxis
Zdroj:	Drug Development Research. 3:213-219
ISSN:	1098-2299 0272-4391
DOI:	10.1002/ddr.430030303
Popis:	In vitro models of anaphylaxis such as the release of mediators from the mast cell can do more than identify compounds with intrinsic anti-allergic activity; they have the potential for development of a detailed profile of activity that may be compared and contrasted in several ways to that of disodium cromoglycate. These parameters include effects upon (a) immunologic versus nonimmunologic release, (b) IgE- versus IgG-provoked release, (c) timing of compound addition relative to challenge, (d) repeated administration (presence or absence of tachyphylaxis), (e) wash-out of agent (reversibility), and (f) other granulocyte models relative to the mast cell. Use of in vitro models of anaphylaxis in this way allows an early judgment to be made about the extent to which a new compound presents a novel anti-allergic profile.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::861a3a82c5ae071da564f3e808f18383 https://doi.org/10.1002/ddr.430030303 Zobrazit plný text záznamu Plný text