Striking increases in postmortem compared to antemortem drug concentrations in a suicidal overdose: A case report
| Autor: | Othon J. Mena, Susan Stolberg, Phyllis Mallett, Elisabeth A. Haas, Iain M. McIntyre |
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| Rok vydání: | 2015 |
| Předmět: |
Drug
business.industry media_common.quotation_subject education 010401 analytical chemistry Diphenhydramine Poison control Drug overdose medicine.disease 01 natural sciences 0104 chemical sciences Pathology and Forensic Medicine Manner of death 03 medical and health sciences 0302 clinical medicine Anesthesia Injury prevention Hospital admission medicine Verapamil 030216 legal & forensic medicine Medical emergency business media_common medicine.drug |
| Zdroj: | Australian Journal of Forensic Sciences. 48:37-41 |
| ISSN: | 1834-562X 0045-0618 |
| Popis: | Toxicology testing revealed dramatic increases in whole-blood concentrations of verapamil and diphenhydramine in the short time between hospital admission and death (53 min) in a subject (with a history of overdosing) found unresponsive. While some degree of post-mortem redistribution (PMR) would be expected for the drugs found in this case, PMR cannot explain the considerable increases observed. It is recommended that in potential overdose cases without a clear manner of death but for which ante-mortem and post-mortem specimens (including gastric content) are available, all should be analysed and considered in order to make a more definitive conclusion regarding that death. |
| Databáze: | OpenAIRE |
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