A novel strategy for the enantioselective synthesis of the steroidal framework using cascade ring expansion reactions of small ring systems-asymmetric total synthesis of (+)-equilenin

Autor:	Masataka Ihara, Hideo Nemoto, Masahiro Yoshida, Keiichiro Fukumoto
Rok vydání:	1999
Předmět:	Cascade reaction Stereochemistry Cascade Chemistry Organic Chemistry Drug Discovery Enantioselective synthesis medicine Total synthesis Equilenin Ring (chemistry) Biochemistry medicine.drug
Zdroj:	Tetrahedron Letters. 40:907-910
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)02479-4
Popis:	Enantioselective synthesis of (+)-equilenin ( 1 ) utilizing a novel strategy is described. The key steps are two cascade ring expansion reactions of small ring systems; 1) chiral (salen)Mn III complex-catalyzed cascade reaction of cyclopropylidene; 2) Pd II -mediated cascade reaction of the cyclobutanol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::860ae0895fab36491855249a20b2eb26 https://doi.org/10.1016/s0040-4039(98)02479-4 Zobrazit plný text záznamu Full Text from ScienceDirect