An asymmetric approach to the synthesis of a carbon-11 labelled gliotransmitter d-serine
| Autor: | O. Itsenko, Alexander Popkov |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Health Toxicology and Mutagenesis Gliotransmitter Synthon Public Health Environmental and Occupational Health Diastereomer chemistry.chemical_element Pollution Analytical Chemistry Amino acid Serine Nickel Nuclear Energy and Engineering chemistry Glycine Radiology Nuclear Medicine and imaging Stereoselectivity Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 304:455-458 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-014-3670-4 |
| Popis: | Endogenous d-serine, a co-transmitter of glutamate for synaptic N-methyl-d-aspartate receptors, is implicated in an array of health conditions. The feasibility of a rapid asymmetric preparation of carbon-11 labelled gliotransmitter d-serine is demonstrated via the hydroxy-methylation of a chiral nickel(II) complex. Using an automated radiochemistry synthesiser the key intermediate was obtained with 80 % diastereomeric excess in a 1 min reaction. Further optimisation of the starting glycine synthon is possible in order to achieve even higher stereoselectivity of synthesis, which can benefit subsequent separation–deprotection of the diastereomeric intermediate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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