STIM1 ablation impairs exercise-induced physiological cardiac hypertrophy and dysregulates autophagy in mouse hearts
| Autor: | Ingrid M. Bonilla, Stephen Baine, Anastasia Pokrass, Juan Ignacio Elio Mariángelo, Anuradha Kalyanasundaram, Vladimir Bogdanov, Louisa Mezache, Galina Sakuta, Casey M. Beard, Andriy Belevych, Svetlana Tikunova, Radmila Terentyeva, Dmitry Terentyev, Jonathan Davis, Rengasayee Veeraraghavan, Cynthia A. Carnes, Sandor Györke |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Applied Physiology. 134:1287-1299 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00363.2022 |
| Popis: | Store-operated Ca2+ entry (SOCE) has been implicated in pathological cardiac hypertrophy; however, its role in physiological hypertrophy is unknown. Here we report that SOCE is also essential for physiological cardiac hypertrophy and functional adaptations in response to endurance exercise. These adaptations were associated with activation of AKT/mTOR pathway and curtailed cardiac autophagy and degeneration. Thus, SOCE is a common mechanism and an important bifurcation point for signaling paths involved in physiological and pathological hypertrophy. |
| Databáze: | OpenAIRE |
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