Carrier systems in PDT: on the way to novel antitumor drugs
| Autor: | Sonja Andrees, Hugo Scheer, Anja Ruebner-Heuermann, Anja Vervoorts, Peter Oehr, Joerg G. Moser |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Drug
chemistry.chemical_classification Cyclodextrin Stereochemistry media_common.quotation_subject Immunogenicity medicine.medical_treatment Tumor specific Photodynamic therapy Combinatorial chemistry Porphyrin chemistry.chemical_compound Monomer chemistry polycyclic compounds medicine Molecule media_common |
| Zdroj: | Proceedings of SPIE. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.199131 |
| Popis: | A novel mode to apply photosensitizing drugs specifically to tumor tissue using the principles of polyphasic tumor therapies is outlined. Key compounds are tumor specific functionalized antibodies with reduced immunogenicity. These bind to drug inclusion complexes in a multiplicative manner. Drug inclusion complexes are designed on the basis of tethered functionalized (beta) -cyclodextrin dimers with maximum affinity to porphyrinoid photosensitizers forming monomeric chlathrates. To enhance porphyrin-cyclodextrin interaction peripheral groups of the porphyrin have to be chemically modified. The development of the method is not yet completed. First results are demonstrated. |
| Databáze: | OpenAIRE |
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