| Autor: |
Masami Miyake, Kazuo Mikami, Takeshi Ueda, Koichiro Akakura, Haruo Ito, Ken' Ichi Mizoguchi, Kazushiro Takei, Masatoshi Noda |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
International Journal of Urology. 10:293-296 |
| ISSN: |
0919-8172 |
| DOI: |
10.1046/j.1442-2042.2003.00634.x |
| Popis: |
Aim: Urinary concentration of oxalate is considered an important factor in the formation of renal stones. Dietary oxalate is a major contributor to urinary oxalate excretion in most individuals. Furthermore, oxalate degrading bacteria have been isolated from human feces. We investigated the significance of oxalate degrading bacteria for urinary oxalate excretion and urinary stone formation. Methods: Twenty-two known calcium oxalate stone-forming patients (stone formers) and 34 healthy volunteers (non-stone formers) were included in the study. Stool specimens were inoculated into pepton yeast glucose (PYG) medium supplemented with oxalate under anaerobic condition at 37 C for one week. After the incubation period, each colony was checked for the loss of oxalate from the culture medium. A 24-h urine sample was collected in 43 individuals and analyzed for oxalate excretion. Results: Twenty-eight of 34 (82%) healthy volunteers and 10 of 22 (45%) calcium oxalate stone formers were colonized with oxalate degrading bacteria. Calcium oxalate stone formers were more frequently free of oxalate degrading bacteria (P 40 mg/day) was found in four of 27 individuals (15%) with oxalate degrading bacteria compared to seven of 16 (44%) without oxalate degrading bacteria (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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