Reduced expression of the DNA glycosylase gene MUTYH is associated with an increased number of somatic mutations via a reduction in the DNA repair capacity in prostate adenocarcinoma

Autor:	Yusuke Inoue, Hong Tao, Hisaki Igarashi, Haruhiko Sugimura, Masanori Goto, Hiroshi Furuse, Kazuya Shinmura, Yuichi Kawanishi, Kimio Yoshimura, Hisami Kato, Seiichiro Ozono, Takayuki Sugiyama
Rok vydání:	2016
Předmět:	0301 basic medicine Cancer Research DNA repair Somatic cell Biology medicine.disease Molecular biology 03 medical and health sciences Prostate cancer 030104 developmental biology medicine.anatomical_structure Germline mutation DNA glycosylase MUTYH Prostate medicine Molecular Biology Gene
Zdroj:	Molecular Carcinogenesis. 56:781-788
ISSN:	0899-1987
Popis:	8-Hydroxyguanine (8OHG), a major oxidative DNA lesion, is known to accumulate in prostate cancer; however, the status of one of its repair enzymes, MUTYH, in prostate cancer remains to be elucidated. In this study, we showed that the expression levels of MUTYH mRNA and protein were significantly lower in prostate cancer than in non-cancerous prostatic tissue by examining two independent, publicly available databases and by performing an immunohistochemical analysis of prostate cancer specimens obtained at our hospital, respectively. About two-thirds of the prostate cancers exhibited a reduced MUTYH expression. When the effect of reduced MUTYH expression in prostate adenocarcinoma on the somatic mutation load was examined using data from the Cancer Genome Atlas (TCGA) database, the numbers of total somatic mutations and somatic G:C to T:A mutations were significantly higher in the reduced MUTYH expression group than in the other group (P
Databáze:	OpenAIRE
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