Rearrangement of unactivated N-alkyl-O-benzoyl hydroxamic acid derivatives with phosphazene bases

Autor:	Yassair S. S. Al-Faiyz, Andrew J. Clark, Divya Patel, Michael J. Broadhurst
Rok vydání:	2001
Předmět:	Steric effects chemistry.chemical_classification Hydroxamic acid Stereochemistry Organic Chemistry Substituent Biochemistry Medicinal chemistry Reaction rate chemistry.chemical_compound chemistry Drug Discovery Alkyl Phosphazene
Zdroj:	Tetrahedron Letters. 42:2007-2009
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)00062-4
Popis:	The phosphazene super bases BTPP 5 , P-2- t Bu 6 , and P-4- t Bu 7 mediate the rearrangement of unactivated N -alkyl- O -benzoyl hydroxamic acid derivatives 8 , 11a – f , 13 and 16 to give 2-benzoyloxy amides 9 , 12a – f , 14 and 17 . The rate of reaction was found to be dependant upon the steric nature of the N -alkyl substituent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85fdc93de2ad619e047cb57939ce86a5 https://doi.org/10.1016/s0040-4039(01)00062-4 Zobrazit plný text záznamu Full Text from ScienceDirect