Antileishmanial evaluation of triazole–butenolide conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions
| Autor: | Alka Raj Pandey, Suriya Pratap Singh, Karthik Ramalingam, Kanchan Yadav, Amol Chhatrapati Bisen, Rabi Sankar Bhatta, Mrigank Srivastava, Renu Tripathi, Neena Goyal, Koneni V. Sashidhara |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | RSC Medicinal Chemistry. |
| ISSN: | 2632-8682 |
| DOI: | 10.1039/d2md00464j |
| Popis: | Synthesis of a novel series of 23 triazole–butenolide conjugates utilizing click chemistry and their antileishmanial, antimalarial, and antifilarial activity along with SAR, ADME predictions and pharmacokinetic study are discussed. |
| Databáze: | OpenAIRE |
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