DEXAMETHASONE INCREASES URINARY EXCRETION OF UREA AND AMINO ACIDS IN PRETERM INFANTS

Autor:	Ronald A. Chalmers, Anthony F Williams, Timothy M Taylor, Mark G. Jones
Rok vydání:	1992
Předmět:	Alanine chemistry.chemical_classification medicine.medical_specialty Ornithine Amino acid Excretion Glutamine chemistry.chemical_compound Endocrinology chemistry Urea cycle Internal medicine Pediatrics Perinatology and Child Health medicine Urea Citrulline
Zdroj:	Pediatric Research. 32:625-625
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-199211000-00120
Popis:	We have shown marked increases in the plasma amino acid concentrations of very low birth weight (VLBW) infants treated with dexamethasone (Arch Dis Child 1992; 67: 5-9). Ornithine, citrulline, alanine and glutamine increased most. We now report rates of urinary excretion Methods: 24-hour urine collections in 6 VLBW infants before and after 48 hours of dexamethasone (0.6 mg kg−1 d−1). Amino acids were measured by high performance liguid chromatography (HPIC). Results: Median values given (n=6 unless indicated). Conclusion: Increased excretion of both the end product and intermediate compounds of the urea cycle support the suggestion that changes in plasma amino acid concentrations result from catabolism rather than inhibition of nitrogen disposal.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85f9e9ff36de39c1c8c7e99be80bb33c https://doi.org/10.1203/00006450-199211000-00120 Zobrazit plný text záznamu