Anti-endotoxin immunotherapy for canine parvovirus endotoxaemia

Autor:	S. L. Gaffin, B. C. Wessels
Rok vydání:	1986
Předmět:	medicine.medical_specialty Treated group biology Treatment regimen business.industry animal diseases viruses medicine.medical_treatment Canine parvovirus Immunotherapy Disease biology.organism_classification Gastroenterology Internal medicine Immunology medicine Small Animals business
Zdroj:	Journal of Small Animal Practice. 27:609-615
ISSN:	1748-5827 0022-4510
DOI:	10.1111/j.1748-5827.1986.tb03760.x
Popis:	The morbidity and mortality associated with canine parvovirus disease (CPV) is caused, in part, by endotoxin (LPS). Equine anti-endotoxin hyperimmune plasma (Anti-LPS) was administered to 89 CPV patients in addition to conventional therapy. In Anti-LPS treated CPV patients mortality was lower (16-8 per cent, 15/89) than in controls that received conventional therapy alone (66-7 per cent, 24/36, P < 0–0005). The hospitalization period of survivors was reduced from 8-5 ± 4-0 days (controls) to 5-2 ± 2-0 days (Anti-LPS treated group). These results suggest that an anti-endotoxin specific therapy should be incorporated into the treatment regimen of CPV, and possibly, other canine enteric disorders, known to produce endotoxaemia.
Databáze:	OpenAIRE
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