Diazotrifluoroethyl Radical: A CF3-Containing Building Block in [3 + 2] Cycloaddition

Autor:	Nan-Wei Wan, Wenyong Han, Chun-Yang He, Yongzheng Chen, Yong-Chao Shao, Jia-Li Huang, Baodong Cui, An-Ni Wang, Wen-Wen Zhao
Rok vydání:	2021
Předmět:	Chemistry Organic Chemistry Hypervalent molecule Biochemistry Combinatorial chemistry Cycloaddition Metal visual_art Reagent Block (telecommunications) visual_art.visual_art_medium Photocatalysis Reaction system Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 23:9256-9261
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c03603
Popis:	We present herein a visible-light-induced [3 + 2] cycloaddition of a hypervalent iodine(III) reagent with α-ketoacids for the construction of 5-CF3-1,3,4-oxadiazoles that are of importance in medicinal chemistry. The reaction proceeds smoothly without a photocatalyst, metal, or additive under mild conditions. Different from the well-established trifluorodiazoethane (CF3CHN2), the diazotrifluoroethyl radical [CF3C(·)N2], a trifluoroethylcarbyne (CF3CĊ:) equivalent and an unusual CF3-containing building block, is involved in the present reaction system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85ef7b3daa6dcf8d70fd0e05cfa3d996 https://doi.org/10.1021/acs.orglett.1c03603 Zobrazit plný text záznamu