Control of stereoselectivity in samarium metal induced cyclopropanations. Synthesis of 1,25-dihydroxycholecalciferol

Autor:	K. Toth, Peter Michael Wovkulich, J. Kiegiel, Milan R. Uskokovic, Noal Cohen, M. M. Kabat
Rok vydání:	1991
Předmět:	chemistry.chemical_classification Ketone Bicyclic molecule Cyclopropanation Stereochemistry Organic Chemistry chemistry.chemical_element Biochemistry Catalysis Samarium Stereospecificity chemistry Drug Discovery Stereoselectivity Aliphatic compound
Zdroj:	Tetrahedron Letters. 32:2343-2346
ISSN:	0040-4039
Popis:	1,25-Dihydroxycholecalciferol (23) was synthesized from A-ring precursor 18 and Windaus-Grundmann ketone 19 via cyclovitamin D 21. Key reactions include highly stereoselective (5 to 6) and stereospecific (13 to 14) cyclopropanations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85e74778c7edfde81bc4c71fdcae7805 https://doi.org/10.1016/s0040-4039(00)79919-9 Zobrazit plný text záznamu