POST-RESECTION REGENERATION OF THE LIVER IN CASE OF RETRORSIN-INDUCED LESION

Autor:	D. R. Petrenyov, S. L. Achinovich, B. B. Osipov, A. N. Lyzikov, A. G. Skuratov
Rok vydání:	2016
Předmět:	Lesion medicine.medical_specialty business.industry Regeneration (biology) medicine medicine.symptom business Resection Surgery
Zdroj:	Health and Ecology Issues. :66-72
ISSN:	2708-6011 2220-0967
Popis:	Objective: to study the regenerative processes of the liver affected by retrorsin after its resection and to assess the reparative role of mesenchymal stem cell transplantation in experiment. Material and methods. Wistar laboratory rats; mesenchymal stem cells from adipose tissue (isolation, cultivation); experimental model of retrorsin-induced hepatitis; liver resection; intraportal introduction of mesenchymal stem cells; light microscopy, morphometry. Results. Using the models of hepatic insufficiency (liver resection, chronic hepatitis) we showed the liver regeneration, whose mechanism involved proliferation of mature hepatocytes (increased mitotic activity, increased cell nuclear device) and biliary ductal epithelial cells. Conclusion. Intraportal administration of autologous MSCs into animals with retrorsin-induced hepatitis contributed to the enhancement of regenerative processes in the liver after its resection in comparison with the control data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85e5d021a2b4f6d1ebc70a17703a7d3a https://doi.org/10.51523/2708-6011.2016-13-1-14 Zobrazit plný text záznamu