P0236COMPARISON OF THE CHARACTERISTICS AND SEVERITY OF RESTLESS LEG SYNDROME AND INSOMNIA IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND RENAL TRANSPLANT RECIPIENTS
| Autor: | Anila Duni, Andrikos Aimilios, Paschalis Steiropoulos, Athanasios Konstantinidis, Haralambos Pappas, Evangelia Ntounousi, Maria Pappa, Olga Balafa, Elisabeth Kokkolou, Karolos Pavlos Rapsomanikis, Ioannis Pnevmatikos, Georgios Dimakopoulos, Michalis Mitsis |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Nephrology Dialysis Transplantation. 35 |
| ISSN: | 1460-2385 0931-0509 |
| Popis: | Background and Aims Symptoms of restless legs syndrome (RLS) are common in patients with chronic kidney disease (CKD) and on dialysis, affecting up to 25% of patients when the international RLS diagnostic criteria are applied. RLS has been associated with disordered sleep, impaired quality of life, increased cardiovascular morbidity and mortality risk in patients with CKD. The aim of our study was to examine the relationship between RLS and the prevalence and severity of insomnia in non-dialysis CKD patients (CKD stage IV and V), in haemodialysis and PD patients, in renal transplant recipients (RTRs) as well as to identify the risk factors independently associated with RLS prevalence and severity in each group. Method 436 patients were included in the study (152 patients with CKD stage IV and V, 117 haemodialysis patients, 78 PD patients and 89 RTRs). RLS diagnosis was made according to IRLSSG diagnostic criteria. The questions of the IRLSSG Severity Scale were answered. Athens Insomnia Scale (AIS) was used for the diagnosis of insomnia. Statistical analysis was performed with appropriate parametric and non-parametric tests and regression analysis models. Results Applying the IRLSSG criteria for diagnosis, the prevalence of RLS was 17%, 25.9%, 26.5%, 32.1% and 16.9% in patients with CKD stage IV, CKD stage V, hemodialysis patients, PD patients and RTRs respectively. The mean severity of the syndrome was higher in PD patients (14.64), followed by haemodialysis patients (12), CKD stage V patients (11.9), KTRs (11.3) and patients with CKD stage IV patients (10.5). Prevalence of RLS did not significantly differ between groups. CKD patients displayed the lowest presence of insomnia, while PD patients showed the relatively highest presence of insomnia. The mean severity of insomnia differed between the pairs: RTRs vs PD patients, RTRs vs haemodialysis patients and PD patients vs patients with CKD stage IV and V (p Conclusion The prevalence and severity of RLS and insomnia worsen as kidney function deteriorates in CKD patients, being most burdensome among patients with stage V CKD, haemodialysis and PD patients. The severity of insomnia is especially increased in PD patients. Although the frequency of RLS decreases in KTRs, it still occurs at higher rates compared to the general population. Further studies are needed to investigate the relationship between RLS and associated risk factors in patients with CKD and following kidney transplantation. |
| Databáze: | OpenAIRE |
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