Oxytocin and ‘social hyperthermia’: Interaction with β3-adrenergic receptor-mediated thermogenesis and significance for the expression of social behavior in male and female mice
| Autor: | Alexander-Quang Duc Tran, Christopher Harshaw, Jessica Lanzkowsky, Mark Jaime, Alana Rose Bradley |
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| Rok vydání: | 2021 |
| Předmět: |
Beta-3 adrenergic receptor
medicine.medical_specialty Endocrine and Autonomic Systems Biology Oxytocin receptor Energy homeostasis Social relation 030227 psychiatry 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Endocrinology medicine.anatomical_structure Oxytocin Internal medicine Brown adipose tissue medicine Thermogenesis 030217 neurology & neurosurgery medicine.drug Social behavior |
| Zdroj: | Hormones and Behavior. 131:104981 |
| ISSN: | 0018-506X |
| DOI: | 10.1016/j.yhbeh.2021.104981 |
| Popis: | Oxytocin (OT) is a critical regulator of multiple facets of energy homeostasis, including brown adipose tissue (BAT) thermogenesis. Nevertheless, it is unclear what, if any, consequence the thermoregulatory and metabolic effects of OT have for the display of social behavior in adult rodents. Here, we examine the contribution of the OT receptor (OTR) and β3 adrenergic receptor (β3AR) to the increase in body temperature that typically accompanies social interaction (i.e., social hyperthermia; SH) and whether SH relates to the expression of social behavior in adult mice. Specifically, we examined how OTR antagonism via peripheral injection of L-368,899 (10 mg/kg) affects the expression of social behavior in C57BL/6J mice, in the presence of active/agonized versus antagonized β3AR, the receptor known to mediate stress-induced BAT thermogenesis. After drug treatment and a 30 min delay, mice were provided a 10 min social interaction test with an unfamiliar, same-sex conspecific. We hypothesized that OTR and β3AR/BAT interact to influence behavior during social interaction, with at least some effects of OT on social behavior dependent upon OT's thermal effects via β3AR/BAT. We found that OTR-mediated temperature elevation is largely responsible for SH during social interaction in mice—albeit not substantially via β3AR-dependent BAT thermogenesis. Further, our results reveal a complex relationship between OTR, β3AR, social hyperthermia and the display of specific social behaviors, with SH most closely associated with anxiety and/or vigilance-related behaviors—that is, behaviors that antagonize or interfere with the initiation of close, non-agonistic social behavior. |
| Databáze: | OpenAIRE |
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