CFTR and FOXO1 gene expression are reduced and high mobility group box 1 (HMGB1) is increased in the ovaries and serum of women with polycystic ovarian syndrome

Autor:	Cecilia Catellani, Francesca Cirillo, Maria E. Street, Alessia Nicoli, Daria Morini, Chiara Sartori, Paolo Giorgi-Rossi, Pietro Lazzeroni, Giovanni Battista La Sala, Sergio Amarri
Rok vydání:	2019
Předmět:	congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment chemical and pharmacologic phenomena 030209 endocrinology & metabolism FOXO1 Inflammation HMGB1 Cystic fibrosis 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Gene expression Medicine Interleukin 6 Loss function 030219 obstetrics & reproductive medicine biology business.industry Insulin Obstetrics and Gynecology respiratory system medicine.disease digestive system diseases respiratory tract diseases biology.protein medicine.symptom business
Zdroj:	Gynecological Endocrinology. 35:842-846
ISSN:	1473-0766 0951-3590
DOI:	10.1080/09513590.2019.1599349
Popis:	We previously described increased HMGB1 and reduced FOXO1 dependent on CFTR loss of function in cystic fibrosis (CF) and we showed in vitro that HMGB1 was lowered by insulin. Reduced CFTR g...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85dae0875c3eb21505c8da2c73207bab https://doi.org/10.1080/09513590.2019.1599349 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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