Synthesis and biological effects of naphthalene-chalcone derivatives
| Autor: | Qing-Hao Jin, Wen-Bo Chen, Hai-Ying Jiang, Li-Ping Guan, Zhi-Yang Fu, Hong-Hai Chen |
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| Rok vydání: | 2020 |
| Předmět: |
Chalcone
010405 organic chemistry Organic Chemistry Central nervous system Analgesic Pharmacology 01 natural sciences Tail suspension test 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Norepinephrine medicine.anatomical_structure chemistry medicine Antidepressant Serotonin General Pharmacology Toxicology and Pharmaceutics Behavioural despair test medicine.drug |
| Zdroj: | Medicinal Chemistry Research. 29:877-886 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-020-02525-4 |
| Popis: | In this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds 2a–2u displayed clear antidepressant activity at 30 mg/kg in the forced swimming test. Compounds 2h, 2o, 2t, and 2u exhibited a good antidepressant effect in the forced swimming test and tail suspension test at 30 mg/kg. Compounds 2h, 2o, 2t, and 2u but had no effect on locomotor activity in the open-field test in mice. In addition, the most antidepressant activity of compound 2o is likely mediated by increased serotonin and norepinephrine levels in central nervous system. Compounds 2a–2u also showed the analgesic and anti-inflammatory effects at 30 mg/kg. |
| Databáze: | OpenAIRE |
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