Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae)
| Autor: | Mariam Ulfah, Khalijah Awang, Agus Safari, Unang Supratman, Asep Supriadin, Desi Harneti, Hideo Hayashi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Meliaceae
biology Chemistry Stereochemistry medicine.medical_treatment Plant Science biology.organism_classification medicine.disease Biochemistry Steroid Leukemia Triterpenoid visual_art medicine visual_art.visual_art_medium Cytotoxic T cell Bark Cytotoxicity Agronomy and Crop Science Biotechnology Aglaia eximia |
| Zdroj: | Phytochemistry Letters. 8:28-31 |
| ISSN: | 1874-3900 |
| Popis: | The new stigmastane steroid, 3,4-epoxy-(22R,25)-tetrahydrofuran-stigmast-5-en (1), along with two known triterpenoids (2–3) and two known steroids (4–5) were isolated from the stem bark of Aglaia eximia. The chemical structures of the new compound were elucidated on the basis of spectroscopic data. All of the compounds were tested for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1–5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 11.42, 4.26, 29.10, 45.96, and 52.09 μg/mL, respectively. |
| Databáze: | OpenAIRE |
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