Distinct Roles of TβRIII and LRP-1 in Lactoferrin-mediated Foxp3+ Inducible Tregs
| Autor: | Sun-Myoung Kim, Young-Saeng Jang, Pyeung-Hyeun Kim |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 202:67.2-67.2 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.202.supp.67.2 |
| Popis: | We recently found that lactoferrin (LF) stimulated mouse naïve CD4+T cells to differentiate into inducible Foxp3+Tregs (iTregs). However, LF decreased cell proliferation, CD62L shedding, and CD44 expression. In the present study, we characterized these phenomena at the receptor level. Addition of excess amount of soluble TβRIII (betaglycan) virtually abrogated the LF-induced Foxp3 expression but little affected LF-suppressed cell proliferation/CD62L shedding/CD44 expression. On the other hand, treatment of anti-LRP-1 Ab slightly enhanced LF-induced Foxp3 expression while substantially restored LF-suppressed cell proliferation/CD62L shedding/CD44 expression. These results indicate that LF enhances Foxp3 expression mainly through TβRIII and simultaneously suppresses cell proliferation/CD62L shedding/CD44 expression mainly through LRP-1. Thus, it is assumed that LF renders activated CD4+T cells to become central memory-like Tregs (CD4+Foxp3+CD62L+CD44lo). |
| Databáze: | OpenAIRE |
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