Asymmetric Heck cyclization route to indolizidine and azaazulene alkaloids: synthesis of (+)-5-epiindolizidine 167B and indolizidine 223AB

Autor:	Gary A. Sulikowski, Mathew Tallant, Kurt Kiewel
Rok vydání:	2001
Předmět:	Indolizidine 223AB chemistry.chemical_compound Formal synthesis Chemistry Stereochemistry Intramolecular force Organic Chemistry Drug Discovery Indolizidine Ring (chemistry) Enantiomeric excess Biochemistry
Zdroj:	Tetrahedron Letters. 42:6621-6623
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)01361-2
Popis:	Asymmetric intramolecular Heck cyclization of endocyclic enamides occurs at room temperature to give indoloizidine and azaazulene ring systems in up to 86% enantiomeric excess. A synthesis of (+)-epiindolizidine 167B and formal synthesis of 5 E ,9 Z -indolizidine 223AB is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85ce34561bb041b93d983045e3e5feea https://doi.org/10.1016/s0040-4039(01)01361-2 Zobrazit plný text záznamu Full Text from ScienceDirect