Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter

Autor:	Constance E. Brinckerhoff, Charles I. Coon, Grant B. Tower, Dany Chalbos, Karine Belguise
Rok vydání:	2003
Předmět:	Promoter Single-nucleotide polymorphism Biology Biochemistry Molecular biology chemistry.chemical_compound chemistry Antigen Transcription (biology) Cancer research SNP Signal transduction Transcription factor DNA
Zdroj:	European Journal of Biochemistry. 270:4216-4225
ISSN:	1432-1033 0014-2956
Popis:	of several cancers and is also associated with non-neoplastic diseases; although the underlying mechanism(s) has yet to be elucidated. In this study we demonstrate that the expression of Fos-like region antigen (Fra-1), an AP-1 transcription factor component that also correlates strongly with neoplastic disease, is necessary for MMP-1 transcription in A2058 melanoma cells. The inhibition of Fra-1 expression preferentially downregulates transcription from the MMP-1 promoter DNA containing the 2G SNP, compared to DNA containing the 1G SNP. This study provides evidence that, in cooperation with the 2G DNA polymorphism, the AP-1 family member, Fra-1, contributes to the high constitutive expression of MMP-1 in melanoma cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85caa9c0fbfb2371b63e57048ed3f9ce https://doi.org/10.1046/j.1432-1033.2003.03821.x Zobrazit plný text záznamu Plný text ve formátu PDF