Synthesis of allobetulin-based asialoglycoprotein receptor-targeted glycoconjugates

Autor:	Yan A. Ivanenkov, Elvira T. Yamansarova, Dmitry A. Skvortsov, Sergei A Evteev, Amina Yu. Adelgareeva, Egor I. Seleznev, Alexander G. Majouga, Emil Yu. Yamansarov, Anton V. Lopuhov, Elena K. Beloglazkina, Natalia L. Klyachko, Elena V Lopatukhina
Rok vydání:	2019
Předmět:	chemistry.chemical_classification chemistry 010405 organic chemistry Stereochemistry Glycoconjugate Asialoglycoprotein receptor General Chemistry Hepatic carcinoma Surface plasmon resonance 010402 general chemistry 01 natural sciences 0104 chemical sciences Conjugate
Zdroj:	Mendeleev Communications. 29:526-528
ISSN:	0959-9436
DOI:	10.1016/j.mencom.2019.09.016
Popis:	New allobetulin conjugates were obtained through its O-esterification with hex-5-ynoic acid followed by [3+2]-cycloaddition with three azido derivatives of N-acetyl- d -galactosamine. The conjugates are non-toxic in micromolar range against hepatocellular carcinoma cell lines and have a high affinity towards the HO asialoglycoprotein receptor of hepatocytes based on molecular docking and surface plasmon resonance data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85c3d7f1dc1165ee894cbbbc5d3fb7f7 https://doi.org/10.1016/j.mencom.2019.09.016 Zobrazit plný text záznamu Full Text from ScienceDirect