A Human T Lymphotropic Virus Type 1 Carrier Coinfected with Mycobacterium intracellulare and Pneumocystis jirovecii with a Characteristic Compositional Change of Bone Marrow Cells
| Autor: | Sayaka Uda, Shinsuke Shiotsu, Ayaka Omura, Ryosuke Hamashima, Akihiro Yoshimura, Naoko Kurisu, Tomoya Sagawa, Koichi Hasegawa, Tatsuya Yuba, Chieko Takumi, Seiko Ono, Noriya Hiraoka |
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| Rok vydání: | 2017 |
| Předmět: |
biology
viruses T-cell leukemia Human T-lymphotropic virus biology.organism_classification medicine.disease Virology Virus Lymphoma 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure immune system diseases hemic and lymphatic diseases 030220 oncology & carcinogenesis parasitic diseases Immunology medicine Pneumocystis jirovecii Bone marrow Immunodeficiency 030215 immunology Mycobacterium |
| Zdroj: | Open Journal of Respiratory Diseases. :110-116 |
| ISSN: | 2163-9418 2163-940X |
| Popis: | Human T lymphotropic virus type 1 (HTLV-1) is endemic in the southern part of Japan. Infection of the virus can cause adult T cell leukemia/lymphoma (ATL), while most infected individuals remain in a carrier state for a long period of time. Although rare cases of carriers, like ATL patients, who developed opportunistic infections, have been reported, hematological changes of carriers who are prone to opportunistic infections have not been well defined. Here, we present a case of an HTLV-1 carrier who developed Mycobacterium intracellulare infection and Pneumocystis jirovecii pneumonia (PcP) simultaneously. Flow cytometric analysis of bone marrow cells revealed an aberrant compositional change similar to that in ATL patients. This suggests the presence of a pre-ATL state prior to the development of ATL, which is notable in terms of underlying cellular immunodeficiency. |
| Databáze: | OpenAIRE |
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