Bone voyage—Osteoblasts remotely control tumors
| Autor: | Haiying Zhang, David Lyden |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Multidisciplinary medicine.medical_treatment Cancer Inflammation Immunosuppression Biology medicine.disease Primary tumor Extracellular matrix 03 medical and health sciences 030104 developmental biology Vasculogenesis medicine Cancer research Adenocarcinoma Epigenetics medicine.symptom |
| Zdroj: | Science. 358:1127-1128 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Cancer is a systemic disease. Tumor growth and malignant progression rely not only on the intrinsic aberrant genetic and epigenetic makeup of tumor cells but also on the tumor-induced systemic factors that affect cells in the primary tumor as well as distant microenvironments ( 1 ). Notably, bone marrow-derived cells (BMDCs) have been shown to contribute to primary tumor progression by promoting hallmark processes such as inflammation, immunosuppression, vasculogenesis, and extracellular matrix remodeling. BMDCs are also involved in establishing tumor-permissive microenvironments that form before the arrival of disseminated tumor cells at future metastatic sites (known as premetastatic niches) and promote metastatic outgrowth ( 2 – 5 ). In addition to the direct effects of tumor-secreted factors on BMDC recruitment to tumors, on page [eaal5081][1] of this issue Engblom et al. ( 6 ) report that osteoblasts, which reside in the bone, can be remotely activated by secreted factors from lung adenocarcinoma, which in turn mobilize a specific subset of BMDCs—neutrophils—to foster tumor growth. [1]: /lookup/doi/10.1126/science.aal5081 |
| Databáze: | OpenAIRE |
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