Viral PDZ Binding Motifs Influence Cell Behavior Through the Interaction with Cellular Proteins Containing PDZ Domains
| Autor: | Isabel Sola, Carlos Castaño-Rodríguez, Javier Gutiérrez-Álvarez, Luis Enjuanes, José M. Honrubia |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
viruses fungi 030302 biochemistry & molecular biology PDZ domain Cell virus diseases Plasma protein binding Biology Dengue virus medicine.disease_cause Virus Cell biology 03 medical and health sciences medicine.anatomical_structure Cell polarity medicine Human genome 030304 developmental biology Coronavirus |
| Zdroj: | Methods in Molecular Biology ISBN: 9781071611654 |
| Popis: | Viruses have evolved to interact with their hosts. Some viruses such as human papilloma virus, dengue virus, SARS-CoV, or influenza virus encode proteins including a PBM that interact with cellular proteins containing PDZ domains. There are more than 400 cellular protein isoforms with these domains in the human genome, indicating that viral PBMs have a high potential to influence the behavior of the cell. In this review we analyze the most relevant cellular processes known to be affected by viral PBM-cellular PDZ interactions including the establishment of cell-cell interactions and cell polarity, the regulation of cell survival and apoptosis and the activation of the immune system. Special attention has been provided to coronavirus PBM conservation throughout evolution and to the role of the PBMs of human coronaviruses SARS-CoV and MERS-CoV in pathogenesis. |
| Databáze: | OpenAIRE |
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