435 RELATIONSHIP BETWEEN PROTEINURIA AND MORTALITY IN CHRONIC SPINAL CORD INJURY
| Autor: | S. J.A. Zaidi, Barry M. Wall, T. M. Mangold, M. W. Greenwell, N. D. Grant |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Creatinine
medicine.medical_specialty education.field_of_study Proteinuria medicine.diagnostic_test business.industry Proportional hazards model Population Urology Renal function General Medicine Hematocrit urologic and male genital diseases medicine.disease General Biochemistry Genetics and Molecular Biology Surgery chemistry.chemical_compound chemistry Diabetes mellitus Medicine Microalbuminuria medicine.symptom business education |
| Zdroj: | Journal of Investigative Medicine. 53:S330.5-S330 |
| ISSN: | 1708-8267 1081-5589 |
| DOI: | 10.2310/6650.2005.00006.434 |
| Popis: | The purpose of the current study was to evaluate the relationship between quantitative proteinuria (measured from 24-hour urine collections obtained 1993-1998) and mortality in chronic spinal cord injury (SCI) patients (n = 220) followed at the VAMC SCI center. Computerized medical records were reviewed in 2004 (follow-up period of 6-11 years) to determine overall mortality. Proteinuria was categorized as normal ( 1 g, n = 31). Long-term survival was assessed by Kaplan-Meier analysis. Regular and stepwise Cox proportional hazards models were used to determine risk factors for mortality. The dependent variable was duration of survival, in months. Independent variables assessed were proteinuria (mg/d), age, duration and type of injury, type of bladder management, ethnicity, diabetes mellitus, hypertension, coronary artery disease, hematocrit, creatinine clearance, and concentrations of albumin, creatinine, and cholesterol. Results Increasing degrees of proteinuria were associated with decreased duration of survival, particularly in patients with > 1.0 g/d. Survival of patients with proteinuria 1.0 g/d (log rank test, p 1.0 g/d proteinuria were significantly older, had longer duration of injury, higher serum creatinine concentrations, lower hematocrit, albumin, and creatinine clearance and were more likely to be paraplegic utilizing indwelling bladder catheters (p Conclusion Proteinuria (> 1 g/d) is associated with decreased survival and impaired log-term renal function, whereas levels of proteinuria associated with microalbuminuria in the general population (150-300 mg/d) were not associated with increased mortality in the SCI population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|