The Preparation of Silk Fibroin Drug-loading Microspheres

Autor:	Rui-Juan Xie, Qi-Ming Deng, Hai-Yan Wu, Jian-Mei Xu
Rok vydání:	2008
Předmět:	Drug Morphology (linguistics) Ethanol General Computer Science media_common.quotation_subject Fibroin Solvent chemistry.chemical_compound SILK chemistry Acetone Particle General Materials Science Nuclear chemistry media_common
Zdroj:	Journal of Fiber Bioengineering and Informatics. 1:73-80
ISSN:	2617-8699 1940-8676
DOI:	10.3993/jfbi06200810
Popis:	This paper deals with the development of a kind of water-in-oil-in-water (w/o/w) multiple-emulsification method to fabricate the SF drug-loading microspheres. The silk fibroin (SF) microspheres were prepared by using SF as vehicle and dexamethasone sodium phosphate (DSP) as drug model. The surface morphology was observed by SEM, the particle diameter and its distribution were observed with Laser particle sizer. The structure was studied by X-ray diffraction and Fourier transform infrared. The properties of drug release were assessed in vitro. The results showed the average size of microspheres varied from 6.53 μm to 68.60 μm. The structure of SF drug-loading microspheres had an obviously change compared with pure SF; and the change is the appearance of silk I and silk II structures; and its molecular conformation was β-sheet. The average drug-loading varied from 5.32 % to 9.01 %, and the average loading varied from 56.43 % to 99.07 %. The drug-loading and loading efficiency increased with the increase of SF concentration. The drug-loading and loading efficiency differed when the treated organic solvent differed, their order is: isopropanol
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85924c81fb3c9e17f17d3cb035f470eb https://doi.org/10.3993/jfbi06200810 Zobrazit plný text záznamu