Calcium-induced ventricular contraction during cardioplegic arrest
| Autor: | Tim R. Love, Gillian A. Geffin, Willard M. Daggett, Brian E. Redonnett, William G. Hendren, Dennis D. O'Keefe, James S. Titus, David F. Torchiana |
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| Rok vydání: | 1987 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Magnesium business.industry chemistry.chemical_element Calcium Creatine Muscle tone chemistry.chemical_compound medicine.anatomical_structure Endocrinology Blood pressure chemistry Internal medicine Anesthesia medicine Ventricular pressure Surgery medicine.symptom Cardiology and Cardiovascular Medicine business Perfusion Muscle contraction |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 94:606-613 |
| ISSN: | 0022-5223 |
| Popis: | Cardiac arrest induced by hyperkalemic perfusion is generally considered to represent a state of complete electromechanical arrest However, high-energy phosphate concentrations and ventricular function decrease with increasing cardioplegic calcium concentrations, possibly because of elevated resting muscle tone produced by calcium influx. We examined isolated rat hearts containing an isovolumic intraventricular balloon for the presence of contractile activity during the administration at 10° C of a cardioplegic solution containing potassium, 20 mEq/L. Significant left ventricular pressure was developed (35.6% ± 4.3% of prearrest systolic pressure) during administration of a solution containing a calcium concentration of 1.0 mmol/L and far less (9.7% ± 1.6% of prearrest systolic pressure) with a calcium-free cardioplegic solution. The muscle contraction diminished with repeated doses, was increased by increasing cardioplegic calcium content, and was inihibited by magnesium. Adenosine triphosphate and creatine phosphate concentrations were 9.0 ± 1.4 and 7.0 ± 0.9 nmol/mg dry weight immediately after infusion of 15 ml of a hypoxic cardioplegic solution containing calcium, versus 13.3 ± 1.3 (p |
| Databáze: | OpenAIRE |
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