| Autor: |
N. Gopalsami, I. Osorio, V. Baranov, Tatiana Lyubynskaya, Gennady G. Kochemasov, V. Eroshenko |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007 ISBN: 9783540730439 |
| Popis: |
A method of thermal suppression of abnormal brain activity observed in epileptic patients during preictal stage was considered for seizure blockage. The development of an implantable brain microcooler as a part of a closed-loop epileptic seizure prevention system is reported. An array of 7 needle-like probes of the diameter ~1 mm and length ~2 cm provides cooling of 1 cubic inch of brain tissue from ~37°C to ~16°C in ~30 sec. Convective method of heat exchange with tube in a tube design was adopted. Two coaxial steel tubes formed channels for the direct and reverse flows of precooled water. Theoretical studies and numerical modeling based on Pennes' equation were performed to investigate the process of brain tissue cooling. Experimental tests demonstrated good agreement with calculations. A closed cycle cooling system with a peristaltic pump and thermoelectric cooling device is being prepared for animal tests. As an additional option a single-probe microcooler of the probe length ~5 cm was developed, fabricated, and tested for cooling of deep brain areas such as hippocampus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
