| Autor: | Michael Roeder, Volker Schurig, Brian D. Klein, H. Steve White, Boris Yagen, Meir Bialer, Nina Isoherranen, Jose H. Woodhead |
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| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
Valpromide Valproic Acid Pharmacokinetic pharmacodynamic Stereochemistry Chemistry medicine.medical_treatment Organic Chemistry Pharmaceutical Science medicine.disease Epilepsy Anticonvulsant Pharmacokinetics medicine Molecular Medicine Valnoctamide Pharmacology (medical) Stereoselectivity Biotechnology medicine.drug |
| Zdroj: | Pharmaceutical Research. 20:1293-1301 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1025069519218 |
| Popis: | Purpose. Racemic valnoctamide (VCD) is a central nervous system- active drug commercially available in Europe. VCD possesses two chiral centers and, therefore, it exists as a mixture of four stereoisomers. The purpose of this study was to evaluate the anticonvulsant activity of two VCD stereoisomers in comparison with VCD (racemate), valpromide (VPD), and valproic acid (VPA) and to study their pharmacokinetic-pharmacodynamic relationships. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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