An Evaluation of Anticoagulant Solutions Used in the Preparation of Platelet Concentrates

Autor:	Harry Lander, M. G. Davey, Raelene L. Kinlough
Rok vydání:	1966
Předmět:	medicine.anatomical_structure medicine.drug_class Chemistry Immunology Anticoagulant Platelet life span medicine Immunology and Allergy Platelet Spleen Hematology Pharmacology
Zdroj:	Transfusion. 6:213-223
ISSN:	1537-2995 0041-1132
DOI:	10.1111/j.1537-2995.1966.tb04727.x
Popis:	Radiochromate-labeled platelet concentrates have been prepared following collection of blood into solutions of EDTA, ACD (formula A), and a more acidic form of citrate-dextrose—ACD ‘S’. Platelet yield was greatest when EDTA was used but following transfusion, relatively few platelets survived in circulation as viable units. In terms of over-all efficiency both solutions of ACD were superior to EDTA. Platelet life span in circulation was unaffected by the anticoagulant used for the collection of blood and would appear to be influenced by both age-dependent and random processes. Surface scintillation counting suggested that in man the majority of effete platelets are normally removed in the liver and that the spleen plays a secondary, but not unimportant, role in this process.
Databáze:	OpenAIRE
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